Bioreactor BSL3

Partner: BILFINGER Industrietechnik Salzburg, Plant location: Guangzhou, China



  • MESControl as supervisory solution server
  • Siemens as host system
  • 4 bioreactors
  • MESControl controls the individual phases
  • Approximately 35 phases per reactor (in total approximately 140 phases)
  • Production and cleaning process (cleaning in place), sterilization (sterilization in place)
  • Process parameters are fully documented and evaluated in MESControl

The bioreactor, developed by Bilfinger Industrial Technology (Bilfinger Industrietechnik) in Salzburg, contains 4 reactors (2 x 500 litres, 2 x 3.000 litres). Since the requirements covering documentation and the evaluation of process data in the area of vaccine production are very high, MESControl was installed as a supervisory system.

MEControl acts as a solution server and control the bioreactor’s management systems (Siemens PCS7). Every production process (formula) in the reactor consists of approximately 35 phases. The individual phases are started by MESControl.

All process parameters and results are stored in the MESControl database.

The production processes, the cleaning in place and sterilisation in place processes are controlled and documented.

Full documentation is guaranteed by the complete acquisition of production values and forms the basis of the evaluations (e.g. batch record).

MESControl is the smart production extension of XAMControl. The system is characterised by its flexibility and quick and easy programming ability. Since the system is built around a database, it is ideally suited for the monitoring and documentation of complex processes.


  • Rene Hirschmugl
    Area Director - Process Control Engineering
  • 0043 3178 21800-146

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